GLP-1 RAs and Reproductive Health: Balancing Benefits, Risks, and Timing

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GLP-1 RAs and Reproductive Health: Balancing Benefits, Risks, and Timing

October 25, 2025 | Family Medicine Exam Prep Course | CCFP

We are excited to see so many of you join our FMEP courses. Several of you have requested we continue to post more practice SAMPs, so here you go!

Just a reminder… pay attention to the questions. Here are our general tips one more time:

1. Pay attention to the questions. Look carefully at how many items you are being asked to list. If the question asks for five items, you will not get more marks if you list eight items; the examiner will look at the first five and allocate marks only for the first five answers so be careful. On a SAMP, if it is not clearly stated how many items you should list, look at the amount of points/marks being allocated for the question to get an idea of how many answers the examiner may be anticipating you write down.

2. Do not write lengthy answers. Most questions can be answered in 10 words or less!

3. Be specific when writing down investigations (hemoglobin instead of CBC; CT abdomen instead of CT).

4. Remember that trade names and generic names are both acceptable when writing down medications.

5. For more helpful tips, you can refer to CCFP’s SAMP instructions by clicking here.

 

SAMP
(5 points)

1. Which of the following conditions is NOT an approved indication for GLP-1 receptor agonists (GLP1RAs) in Canada? (1 point)

    1. Type 2 diabetes
    2. Obesity
    3. Polycystic ovarian syndrome (PCOS)
    4. None of the above
  • Answer: C (Note: GLP1RAs are used off-label for PCOS)

2. Why should patients stop taking GLP1RAs 1-2 months before a planned pregnancy? (1 point)

    1. They can reduce fertility
    2. They may cause gestational diabetes
    3. Preclinical studies show risk of fetal abnormalities
    4. They interfere with implantation
  • Answer: C

3. What is the recommended approach for patients taking GLP1RAs who are planning pregnancy? (1 point)

    1. Continue GLP1RAs until pregnancy is confirmed
    2. Switch to insulin immediately
    3. Use contraception and stop GLP1RAs 1-2 months before conception
    4. Reduce the dose gradually during pregnancy
  • Answer: C

4. What is a common consequence of stopping GLP1RA treatment? (1 point)

    1. Hypoglycemia
    2. Permanent infertility
    3. Rebound weight gain
    4. Menstrual irregularity
  • Answer: C

5. Why are GLP1RAs not recommended during lactation? (1 point)

    1. They are excreted in high amounts in breast milk
    2. They cause milk suppression
    3. There is limited safety data in humans
    4. They increase infant appetite
  • Answer: C
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